Cancer immunotherapy has transformed cancer treatment, yet many patients experience limited or short-lived responses due to ...

New findings reveal how cancer manipulates immune pathways and highlight therapeutic strategies to unleash T-cells against even the most resistant tumors. Study: Cancer cells impair monocyte-mediated ...

Killer immune cells destroy cancer cells and cells infected by virus. These CD8 + T cells are activated after detection of viral infection or growth of “non-self” tumor cells. However, in chronic ...

Major histocompatibility complex class II (MHC-II) molecules play a critical, yet historically overlooked, role in tumor ...

Background Metabolic dysfunction-associated steatohepatitis-related hepatocellular carcinoma (MASH-HCC) has been reported to be less responsive to immune checkpoint inhibitors, which may be associated ...

Clonally expanded CD8+ T cells are key drivers of alopecia areata, mediating epithelial cell death and immune infiltration. JAK inhibitors are approved for AA treatment, but recurrence is common, ...

Recent advancements in cancer vaccine development have demonstrated their potential for precise tumor targeting through antigen-specific immune activation. Nevertheless, critical challenges persist in ...