Artificial antigen-presenting cells (aAPCs) are engineered constructs designed to emulate the functions of professional antigen-presenting cells. By displaying tumour-associated peptide–MHC complexes ...
Loosening chimeric antigen receptor's grip on T-regulatory cells improves function, researchers find
A new paper from MUSC Hollings Cancer Center researchers is helping to reveal the "rules" for engineering chimeric antigen receptor (CAR) Tregs. Tregs, or T-regulatory cells, have shown promise in ...
Pulmonary T and B cells are important for protection of this mucosal barrier site. While viral infections lead to the development of ectopic lymphoid structures highly similar to those in germinal ...
Immune cells called double negative T cells are abundant in the intestine but have been poorly understood till date. In a recent study, researchers from the Institute of Science Tokyo report that ...
New evidence shows that human M cells act as fully fledged antigen-presenting cells, processing and presenting gluten peptides through a dendritic cell-like pathway that may shape early coeliac ...
B lymphocytes exhibit dual roles in tumorigenesis, acting as both allies and adversaries in the tumor microenvironment (TME). Their anti-tumor functions include recognizing tumor-associated antigens, ...
Sjögren's disease is a widespread chronic autoimmune disorder that attacks the body's own glands, yet its underlying disease mechanisms remain poorly understood. In a recent study, researchers from ...
The gastrointestinal tract is continuously exposed to foreign antigens in food and commensal microbes that have the potential to induce adaptive immune responses for food allergies. Upon genetic ...
A decade ago, a clinical trial in the U.K. notably showed that children who were exposed to peanuts in the early months of life had reduced risk of developing a peanut allergy compared with children ...
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