Bone adapts to mechanical force through coupled formation and resorption, a principle central to orthodontics.

In rat bone marrow stem cells, the TLR4 inhibitor TAK-242 suppressed LPS-induced inflammatory gene expression while leaving ...

Osteoporosis researchers do not suffer from a lack of potential drug targets—so one challenge is to decide which ones to ...

PM2.5 exposure accelerated cellular ageing, impaired stem cell function and reduced bone mineral density in diabetic mice.

Orthodontic tooth movement relies on mechanical force to remodel alveolar bone, yet how periodontal ligament (PDL) ...

RUNX2 is best known as a master transcription factor of osteoblast differentiation. Mutations in, or haploinsufficiency of RUNX2 cause CCD, a skeletal disorder characterized by delayed permanent tooth ...

A new study of the PhyloBone project of the University of Turku, Finland, identifies hundreds of non-collagenous proteins in the bone matrix that may play regulatory roles in bone formation and ...

Scientists have identified a protein that blocks the activity of bone-forming cells (osteoblasts) by stopping them from maturing during the journey to sites of bone formation, a new study has found.

Osteocytes are the most abundant cells in mature bone and help maintain skeletal health by coordinating bone formation and breakdown. These long-lived ...

Researchers found that FGFR1 signaling helps organize bone-building material and cellular connections needed for newly ...

Bone is a mineralized connective tissue from which bones, the main component of the vertebrate skeleton, are formed. Bone tissue is composed of cells, namely osteoblasts, osteoclasts and osteocytes, ...