Effective cancer immunotherapy relies not only on antigen recognition by T and B lymphocytes but also on co-stimulatory signals that reinforce activation, expansion and memory formation. T cells ...

Significant progress in understanding T cell signalling, particularly with respect to T cell co-receptors such as the co-stimulatory receptor CD28, has been made in recent years. This knowledge has ...

Inducible co-stimulation via the ICOS pathway is a key mechanism by which activated T cells receive signals that enhance proliferation, survival and effector functions. Engagement of ICOS on T cells ...