A research group has uncovered important details about how platelet-activating factor (PAF)—a powerful molecule involved in inflammation and allergic reactions—triggers contractions in the smooth ...

A study in human prostate tissues finds that inhibitors of the Rab GTPases Rab7 and Rab27 fail to consistently alter ...

Different tissues need different amounts of blood depending on what they are doing. Meeting those changing demands requires the circulatory system to continually balance how much blood flows to ...

A research group led by Dr. Keisuke Obara, Dr. Kento Yoshioka, and Professor Yoshio Tanaka from the Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, has ...

The flow of water within a muscle fiber may dictate how quickly muscle can contract, according to a University of Michigan study. Nearly all animals use muscle to move, and it's been known for a long ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

DHA has previously been shown to inhibit voltage-dependent Ca 2+ channels (VDCCs). The research group found a new pharmacological action of DHA to inhibit the Orai1 channel, which is one of ...