Tail handling of laboratory mice has become increasingly criticized and the refinement principle of the 3Rs calls for the adoption of less aversive handling methods. Tunnel handling has emerged as a ...

Mice are the most common animal used in research. Many routine procedures (including blood pressure measurement, injections, and blood collection) require the mouse to be restrained. As manual ...

Current mouse handling methods during cage change procedures can cause stress and potentially compromise animal welfare. Our previous study of breeding C57BL/6J mice found modest increases in pup ...