Autophagy and lysosomal pathways orchestrate unconventional secretion of Parkinson's disease protein
Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...
Avenue Biosciences received $5.7 million in seed extension to scale a high-throughput protein engineering technology designed to accelerate the discovery of protein-based tools and therapies. Balnord ...
A novel reporter protein has been developed to enable the investigation of protein biogenesis in the ER and its disruption in disease. A recent research collaboration between multiple Japanese ...
Osaka, Japan – Our cells carry out hundreds of thousands of important functions every day, all of which are carefully orchestrated at a microscopic scale. However, the precise mechanisms that ...
These modifications enabled the establishment of a vacuolar transport route unique to seed plants. Plants contain two major types of VAMP7 proteins: VAMP71, which functions in vacuolar membrane fusion ...
First-in-human phase I study of HSK41959, an MTA-cooperative PRMT5 inhibitor, in patients with MTAP-deleted advanced solid tumors. A rationally designed local delivery platform (OncoPLEX) for ...
Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...
Autophagy and lysosomal pathways orchestrate unconventional secretion of Parkinson’s disease protein
Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...
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