It's already Week 6 of the 2025 NFL season. Here's a look at expert predictions, picks against the spread and odds for every game on the schedule.

At Caesars Superdome on Sunday, the New England Patriots (3-2) take on the New Orleans Saints (1-4).

Game time: 9:30 a.m. ET Game location: Tottenham Hotspur Stadium in London, England TV channel: NFL Network

Joe Flacco makes his Bengals debut, while Dak Prescott looks to continue rolling vs. the Panthers. (Frank Bowen IV / The Enquirer / USA Today via Imagn Images; Sarah Stier / ) Nothing like a trade to throw some spice into the middle of an NFL season.

The Cincinnati Bengals are officially the hardest team to predict in the NFL as they head into Sunday's Week 6 encounter with the Green Bay Packers.