Voltage-activated proton (Hv) channels are essential components in the innate immune response. Hv channels are dimeric proteins with one proton permeation pathway per subunit. It is unknown how Hv ...

MEDFORD/SOMERVILLE, Mass. (October 7, 2019)--Scientists at Allen Discovery Center at Tufts University and Harvard Medical School have revealed how, in the case of limb formation, the electrical ...

This is a preview. Log in through your library . Abstract The hydrophobic gasket (HG), a ring of hydrophobic amino acids in the voltage-sensing domain of most voltage-gated ion channels, forms a ...

Ion channels are transmembrane proteins specifically involved with the transport of inorganic ions like Na+, K+, Ca2+, or Cl-. Ion channels are “gated”, i.e. they open in response to a specific ...

Gefitinib in Combination With Paclitaxel and Carboplatin in Advanced Non–Small-Cell Lung Cancer: A Phase III Trial—INTACT 2 Hu antibodies previously have been associated with longer survival of ...

Though the cell membrane is a protective barrier, it also plays a role in letting some foreign material in -- via ion channels that dot the cell's surface. Now new research from the Nobel ...

Ion channels are membrane proteins, which play a principal role in regulating cellular excitability. They are found in virtually all cells, and are of crucial physiological importance. Based on the ...

Researchers at the University of California, Irvine, have uncovered an unexpected molecular partnership that reshapes ...

Electrophysiological studies were conducted on the cloned plant cyclic nucleotide-gated ion channels AtCNGC2 and AtCNGC1 from Arabidopsis, and NtCBP4 from tobacco (Nicotiana tobacum). The nucleotide ...

Ligand-gated ion channels (LGICs) represent an important class of drug targets that play a critical role in the function of the central nervous system. Compounds acting on ligand-gated channels are ...