The Auburn Tigers and Florida Gators meet in an all-SEC clash to kick off the Final Four on Saturday. Then, the Duke Blue Devils square off with the Houston Cougars in the nightcap in San Antonio. Each battle between No. 1 seeds could produce games that are talked about for decades.

Auburn basketball survived 2-seed Michigan State on Sunday, advancing to its second Final Four in six seasons. Next up for the Tigers? A familiar foe.

The 2025 NCAA Men’s Basketball tournament will be available across CBS, TBS, TNT, and truTV. (1) Florida vs. (1) Auburn, 6:09 p.m. on CBS

According to DraftKings, Duke (+110) has the best odds to win the title entering the Final Four. Florida (+250), Houston (+400) and Auburn (+475) round out the rest of the Final Four teams. Gambling problem? Call (877-8-HOPENY) or text HOPENY (467369).

By bypassing the Blue Devils for the title, you can differentiate your entry. Duke’s prowess has made it the most popular title pick in ESPN’s bracket contest ( 25 percent of entries as of Tuesday) as well as CBS’s. Not going with Duke to win is a smart pool strategy Mock outlines here — while still collecting points by riding Duke to the finals.

It's a parade of No. 1 seeds along the Riverwalk in San Antonio as the men's NCAA Tournament is down to its Final Four. See the matchups, schedule.

Final Four picks, predictions, odds for Florida Gators vs Auburn Tigers NCAA Tournament March Madness game on Saturday, April 5, 2025. Who wins game?

The top-seeded Tigers will face No. 16 seed Alabama State on Thursday at 1:50 p.m. CT in Rupp Arena in Lexington, Kentucky. The Hornets earned the right to face Auburn by defeating St. Francis on Tuesday, 70-68. Alabama State secured the win thanks to an Amarr Knight layup with 0:01 remaining in the game.