Gut

Luminal–basal stratification of the native human pancreatic duct is differentially represented in pancreatic cancers

Background A resemblance of pancreatic tumours to their native tissue architecture remains largely unexplored, while it may ...
Gut

Environmental impacts of single-use versus reusable duodenoscopes for endoscopic retrograde cholangiopancreatography in Germany: an ISO-compliant cradle-to-grav…

Duodenoscope-associated infections remain a safety concern, and single-use duodenoscopes have been introduced to mitigate ...
Gut

Autoimmune gastritis: a hidden gateway to cardia and oesophageal cancers beyond non-cardia gastric adenocarcinoma

Autoimmune gastritis (AIG) has been traditionally recognised as a precursor to type I gastric neuroendocrine tumours and ...
Gut

From preclinical phase of Crohn’s disease to postoperative recurrence: shared mechanisms and potential interventions

Crohn’s disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract with high risk of surgery. Despite advances in medical treatment, of those patients who undergo ileocolonic ...
Gut

Recent advances in our understanding of the gut microbiome: an analysis from the Gut Microbiota for Health Expert Panel of the British Society of Gastroenterology

At around 10 years ago, at the time of the first publication by the Gut Microbiota for Health Expert Panel of the British ...
gut.bmj

P5 Pegozafermin treatment demonstrates long-term benefit in subjects with metabolic dysfunction-associated steatohepatitis and fibrosis: results from the Phase 2b ENLIVEN ...

Introduction Pegozafermin (PGZ), a long-acting fibroblast growth factor 21 (FGF21) analog, was evaluated for efficacy and safety in the Phase 2b ENLIVEN trial in metabolic dysfunction-associated ...
gut.bmj

Selenium, senescent neutrophils and the expanding biology of selenoprotein P in cancer

Despite the transformative impact of immune checkpoint inhibitors in oncology, hepatocellular carcinoma (HCC) remains stubbornly resistant in many patients, with durable responses to combination ...
gut.bmj

Mechanisms of intestinal adaptation in short bowel syndrome: what is the evidence?

Short bowel syndrome (SBS) is defined by a remaining small bowel length of less than 200 cm after surgical resection and is a condition with significant clinical implications and a high risk of ...
gut.bmj

Satavaptan for the management of ascites in cirrhosis: efficacy and safety across the spectrum of ascites severity

7 Liver Unit, Hospital Clinic, University of Barcelona, IDIBAPS (Institut d'Investigacions Biomèdiques August Pi-Sunyer), CIBEReHD (Centro de Investigación Biomédica en Red Enfermedades Hepáticas y ...
gut.bmj

Colon and rectal cancer survival in seven high-income countries 2010–2014: variation by age and stage at diagnosis (the ICBP SURVMARK-2 project)

Objectives As part of the International Cancer Benchmarking Partnership (ICBP) SURVMARK-2 project, we provide the most recent estimates of colon and rectal cancer survival in seven high-income ...
gut.bmj

Human milk oligosaccharide DSLNT and gut microbiome in preterm infants predicts necrotising enterocolitis

Objective Necrotising enterocolitis (NEC) is a devastating intestinal disease primarily affecting preterm infants. The underlying mechanisms are poorly understood: mother’s own breast milk (MOM) is ...
gut.bmj

Global prevalence of self-reported non-coeliac gluten and wheat sensitivity: a systematic review and meta-analysis

Background Non-coeliac gluten/wheat sensitivity (NCGWS) is characterised by gastrointestinal and extraintestinal symptoms related to gluten or wheat ingestion in individuals without coeliac disease or ...