Their clinical AD data analysis began with a GWAS on a clinical AD cohort in which nearly half of participants had non-European ancestry, the dataset from the National Institute on Aging Genetics of ...

This new cryo-EM structure represents a remarkable advance in our understanding of how human PINK1 is stabilized” said ...

Spatial transcriptomics on human brains parsed microglial reactions to amyloid immunotherapy. Both a vaccine and a therapeutic antibody summoned these cells to plaques. Responders expressed TREM2, ...

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Numerous studies have hinted that women are particularly susceptible to tau pathology, but scientists have lacked definitive data. Now, a meta-analysis of six longitudinal tau PET studies offers the ...

Autoimmunity and Alzheimer’s. People with autoimmune disorders in the UCSF (left) and Stanford medical systems (right) were ...

Sex Delta by Cell Type. In men with Alzheimer’s (top left), B cells (red boxes) were fewer (blue), while NK cells (blue boxes ...

The fragments also directly compromise synapses they encounter along the way, according to a preprint posted February 24 on bioRxiv. Specifically, tau fragments containing the microtubule binding ...

Erythropoietin-producing hepatocellular (Eph) receptors, including EphA4, are expressed on the cell surface and involved in brain development, which involves extensive pruning of synapses. A variant ...

Protective borders between the brain and the blood weaken with age. This includes the barrier formed by tightly linked epithelial cells in the choroid plexus, which generates cerebrospinal fluid. In ...