Parkin KO Mouse | ALZFORUM
Dec 17, 2024 · These parkin knockout (KO) mice were generated by creating a germline disruption in the parkin gene within exon 3 leading to a truncated transcript coding for the first …
Pretty in PINK1, Cryo-EM Reveals How Kinase Anchors to …
Mar 14, 2025 · From this perch, PINK1’s kinase domain springs into action, phosphorylating ubiquitin, which recruits the ubiquitin ligase Parkin—another PD-linked protein—to tag …
Dopamine covalently modifies and functionally inactivates parkin ...
Oct 26, 2005 · Therefore, the authors proposed that parkin is a direct molecular target of oxidized dopamine, and the dopamine-induced loss of parkin activity represented a possible …
Structure of human PINK1 at a mitochondrial TOM-VDAC array
Mar 14, 2025 · One way is through the PINK1-Parkin mitophagy pathway, with PINK1 serving as the damage sensor (reviewed in Narendra and Youle, 2024). PINK1 is targeted to all …
Curcuma wenyujin extract alleviates cognitive deficits and restrains ...
Qi Y, Zhang J, Zhang Y, Zhu H, Wang J, Xu X, Jin S, Wang C, Zhang F, Zhao M, Wu Z, Zhu H, Yan P. Curcuma wenyujin extract alleviates cognitive deficits and restrains pyroptosis through …
Loss of Parkin reduces inflammatory arthritis by inhibiting p53 ...
Jung YY, Son DJ, Lee HL, Kim DH, Song MJ, Ham YW, Kim Y, Han SB, Park MH, Hong JT. Loss of Parkin reduces inflammatory arthritis by inhibiting p53 degradation. Redox Biol. 2017 …
Familial Parkinson disease gene product, parkin, is a ubiquitin …
Mar 13, 2003 · Shimura H, Hattori N, Kubo Si, Mizuno Y, Asakawa S, Minoshima S, Shimizu N, Iwai K, Chiba T, Tanaka K, Suzuki T. Familial Parkinson disease gene product, parkin, is a …
Pink1 KO Rat - ALZFORUM
Jan 13, 2018 · Outlook of PINK1/Parkin signaling in molecular etiology of Parkinson's disease, with insights into Pink1 knockout models. Zool Res. 2023 May 18;44 (3):559-576. PubMed. …
Parkin is a disease modifier in the mutant SOD1 mouse model of …
Palomo GM, Granatiero V, Kawamata H, Konrad C, Kim M, Arreguin AJ, Zhao D, Milner TA, Manfredi G. Parkin is a disease modifier in the mutant SOD1 mouse model of ALS.
Structural basis for the pathogenicity of parkin catalytic domain ...
Wagner JP, Sauvé V, Saran A, Gehring K. Structural basis for the pathogenicity of parkin catalytic domain mutants. J Biol Chem. 2025 Jan;301 (1):108051. Epub 2024 Dec 3 PubMed.